Interactions Between Genetic and Epidemiological Factors Influencing Mammographic Density.

Austin Hammermeister Suger; Hongjie Chen; Cameron B Haas; Shaoqi Fan; Christopher G Scott; Manjeet K Bolla; Joe Dennis; Alison M Dunning; Kyriaki Michailidou; Qin Wang; Peter A Fasching; Lothar Haeberle; Jennifer Stone; Manuela Gago-Dominguez; Jose E Castelao; Rachel A Murphy; Kristan Aronson; Fergus J Couch; Siddhartha Yadav; Roger L Milne; John L Hopper; Aaron Norman; A Heather Eliassen; William J Tapper; Diana M Eccles; D Gareth Evans; Susan Astley; Per Hall; Kamila Czene; Paul DP Pharoah; Antonis C Antoniou; Montserrat García-Closas; Amy Berrington; Douglas F Easton; Gretchen L Gierach; Rulla M Tamimi; Celine M Vachon; Sara Lindström; Tabitha A Harrison

Journal article

Interactions Between Genetic and Epidemiological Factors Influencing Mammographic Density.

Austin Hammermeister Suger, Hongjie Chen, Cameron B Haas, Shaoqi Fan, Christopher G Scott, Manjeet K Bolla, Joe Dennis, Alison M Dunning, Kyriaki Michailidou, Qin Wang, Peter A Fasching, Lothar Haeberle, Jennifer Stone, Manuela Gago-Dominguez, Jose E Castelao, Rachel A Murphy, Kristan Aronson, Fergus J Couch, Siddhartha Yadav, Roger L Milne Show all

Am J Epidemiol | Published : 2025

DOI: 10.1093/aje/kwaf067

Abstract

Studies have identified genetic and epidemiological factors associated with mammographic density (MD) phenotypes. However, MD-associated genetic variants only account for a small proportion of the total estimated heritability. Interrogating interactions between genetic and epidemiological factors could potentially identify additional MD-associated loci, expand our understanding of the genetic basis of MD phenotypes, and clarify how epidemiological factors modulate relationships between genetic variants and MD. We conducted six separate genome-wide, gene-environment (GxE) interaction analyses, applying 2 degrees of freedom (df) and 1df interaction tests, for each of three MD phenotypes (perce..

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